Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (5): 295-297.doi: 10.3969/j.issn.1004-616x.2005.05.011

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Electronic Microscopic Obser-vation on the Effect of Photody-namic Therapy on Esophageal Carcinoma Cells

ZHANG Yan-mei; SHI Gang-gang;LI Wei-qiu;ZHUANG Bing-rong; LIU Chi;SHEN Zhong-ying   

  1. Department of Pharmacology,Shantou University Medical College,Shantou 515041,Guangdong,China
  • Received:2004-07-07 Revised:2004-08-15 Online:2005-09-30 Published:2005-09-30
  • Contact: ZHANG Yan-mei

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Abstract: BACKGROUND ＆ AIM: To study the effect of photodynamic therapy (PDT)on ultrastructure of esophageal carcinoma cells. MATERIAL AND METHODS: After action of photosensitizer for 6,12,and 24 hours respectively, cultured esophageal carcinoma cells were irradiated with Ultraviolet B(UVB) for half an hour. The ultrastructure of esophageal carcinoma cells in experimental groups and control groups were observed under transmission electron microscope. RESULTS: PDT resulted in condensation of mitochondria,reduction of rough endoplasmic reticulum, dilation of smooth endoplasmic reticulum,breakup of nuclear membrane and pyknosis of nucleolus. The severity of injury of membranous structures increased with the time prolonging of photosensitizer action. CONCLUSION: PDT can do damage to membranous structures of esophageal carcinoma cells,which suggests that PDT may have clinical efficacy for treatment of esophageal carcinoma.

Key words: photodynamic therapy, esophageal carcinoma cell, ultrastructure