胡麻油烟凝聚物诱导人胚肺二倍体细胞恶性转化作用

doi:10.3969/j.issn.1004-616x.2007.01.012

Abstract

Abstract: BACKGROUND ＆ AIM: To study the potential carcinogenic risk of siritch oil fume condensate (SOFC) to human. MATERIALS AND METHODS: Different concentrations of SOFC were co-incubated with human embryo lung diploid cells. The degree of malignant transformation was observed by assessing the biological characteristics of the cells. RESULTS: The concentration of SOFC within the dose range of the experiment(25～400 μg/ml) could induce malignant transformation of the human embryo lung diploid cell, and with an obvious dose-response relationship. Transformed cells exhibited many characteristics associated with malignant transformation, such as losing contact-dependent inhibition, saturated density angmentation, growing at low serum concentration, agglutinating by different concentrations of ConA, losing anchorage dependence, forming tumor at inoculation site of athymic mouse. CONCLUSION: SOFC could induce human embryo lung diploid cell malignant transformation and showed potential carcinogenicity to human.

Key words: siritch oil fume condensates, human embryo lung cell, malignant transformation, athymic mouse

CLC Number:

R994.6

LIU Xiu-fang, LI Li-ping, HU Shang-ping GUO Feng-ying, . Malignant Transformation of the Human Embryo Lung Diploid Cell Induced by Siritch Oil Fume Aggregates[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(1): 40-043.

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Malignant Transformation of the Human Embryo Lung Diploid Cell Induced by Siritch Oil Fume Aggregates

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