胃癌中RhoC和CD44v6的表达及其临床意义

doi:10.3969/j.issn.1004-616x.2008.01.014

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (1): 60-063.doi: 10.3969/j.issn.1004-616x.2008.01.014

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Expressions and Clinical Significance of RhoC and CD44v6 in Gastric Carcinoma

WANG Ping1, YANG Jin_feng1, ZHANG Qing2, CHENG Ze_nong1, Yu Dong_hong1

(1. Anhui Key Laboratory of Infection and Immunology, Department of Pathology，Bengbu Medical College，Bengbu 233003, Anhui; 2. Central Laboratory, Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China)

Received:2007-04-17 Revised:2007-06-24 Online:2008-01-30 Published:2008-01-30

Abstract

Abstract: BACKGROUND AND AIM: To investigate the expressions of RhoC and CD44v6 proteins in gastric carcinoma (GC) and their relationship to clinicopathological factors. MATERIALS AND METHODS: Immunohistochemical staining SP method was used to evaluate the expressions of RhoC and CD44v6 in 97 cases of GC. RESULTS: 75(77.31％) and 81(83.50％)of 97 cases showed overexpressions for RhoC and CD44v6, respectively. There was a significant correlation between the overexpression of RhoC and CD44v6 (P<0.05). The expressions of RhoC and CD44v6 in GC were significantly associated with the depth of tumor invasion and TNM staging(P<0.05). Moreover, the RhoC overexpression was associated with lymph node metastasis(P<0.05). CONCLUSION: Overexpressions of RhoC and CD44v6 proteins are frequent events in GC. Measurement of these protein expressions might be used as a prognostic indicator for GC.

Key words: gastric carcinoma, neoplasm, RhoC, CD44v6, invasion, immunohistochemistry

CLC Number:

R735.2

WANG Ping, YANG Jin_feng, ZHANG Qing, CHENG Ze_nong, Yu Dong_hong. Expressions and Clinical Significance of RhoC and CD44v6 in Gastric Carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(1): 60-063.

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Expressions and Clinical Significance of RhoC and CD44v6 in Gastric Carcinoma

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