Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (3): 220-223.doi: 10.3969/j.issn.1004-616x.2008.03.013

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Effects of Lycium Barvarum Polysaccharides on Reproductive System in Rats with Chronic Psychologic

LI Hong-hui, LIU Xiu-fang,YANG Hui-fang   

  1. Department of Environmental Health, Ningxia Medical College,Yinchuan 750004,China
  • Received:2007-10-10 Revised:2007-12-25 Online:2008-05-30 Published:2008-05-30
  • Contact: LIU Xiu_fang

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Abstract: BACKGROUND AND AIM:To investigate the effects of lycium barvarum polysaccharides(LBP) on the reproductive system in male rats under chronic psychologic stress. MATERIALS AND METHODS: Rats were randomly divided into 6 groups:control group, stress group,high dose LBP group(hLBP),low dose LBP group(lLBP) , hLBP＋stress group and lLBP＋stress group.Sexual homone levels and sexual organ indexes were measured after four weeks. RESULTS: The sperm count and activity were increased significantly, and abnormality percentage was reduced in stress group. LBP protected the spermatogenic cells and promoted the normal development of testicular germ cells. CONCLUSION: LBP could enhance the reproductive function of chronic mentally stressed rats. The mechanism might be through adjustment of hypothalamus_pituitary_gonadal axis and target receptors.

Key words: lycium barvarum polysaccharides(LBP), chronic psychologic stress