Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (4): 275-278.doi: 10.3969/j.issn.1004-616x.2008.04.007

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Selenium_enriched Garlic on the Gastric Juice Components and Upper Gastrointestinal Tract Stimulation in Experimental Animal

LIN Fei1, LIANG Yi1,LU Lian1,YANG Wen_jie2 ,YANG Yan_hua2   

  1. ational Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050; 2. Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijng 100050, China
  • Received:2008-03-24 Revised:2008-05-13 Online:2008-07-30 Published:2008-07-30

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Abstract: BACKGROUND AND AIM: To evaluate the effects of selenium_enriched garlic on the gastric juice components and upper gastrointestinal tract stimulation in rats and beagle dogs. MATERIALS AND METHODS: Selenium_ enriched garlic was given to rats and beagle dogs for 10 days, stimulant response of the upper gastrointestinal tract and changes of the mucous membrane, gastric acid and pepsin of rat gastric juice were determined. RESULTS: The free hydrochloric acid, total acidity and activity and volume of pepsin in rats were obviously inhibited. Gastric secretion and total acidity increased at doses of 1 500 mg/kg and 3 750 mg/kg, and total acid output increased at dose of 3 750 mg/kg. There was gentle stimulation on upper gastrointestinal tract mucosa in rats treated with selenium_enriched garlic. There was gentle stimulation on upper gastrointestinal tract mucosa in beagle dogs treated repeatedly with 200 mg/kg selenium_enriched garlic; and medium stimulation in beagle dogs treated with 350 mg/kg and 450 mg/kg once. CONCLUSION: Selenium_enriched garlic could change the stomach intestine environment, suppress gastric acidity and pepsin enzymatic activity, promote gastric secretion and stimulate upper gastrointestinal tract mucosa.

Key words: Selenium_enriched garlic, rat, dog, gastrointestinal tract stimulation, gastric juice, pepsin