广西黄曲霉毒素B1高污染区210人CYP3A7基因多态性检测

doi:10.3969/j.issn.1004-616x.2008.04.011

Abstract

Abstract: BACKGROUND AND AIM: To investigate polymorphisms of CYP3A7 gene of population in Guangxi with heavy aflatoxin B1 (AFB1)contamination, and the relationship between CYP3A7 genotypes and susceptibility of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Single nucleotide polymorphisms of CYP3A71A and 1C were analyzed in 210 cases and control samples (97 HCC, 38 HBV_positive but with no other disease and 75 HBV_ negative no disease) using the polymerase chain reaction_restriction fragment length polymorphism assays. RESULTS: All of the samples were CYP3A71A/1A genotype ,CYP3A71C allele was not detected in this cohort of Guangxi population. CONCLUSION: CYP3A71C allele was not detected in this cohort,suggesting that CYP3A7 might have a small influence on the development of AFB1_related HCC.

Key words: cytochromes P450 3A7, genetic polymorphism, aflatoxin B1, hepatocellular carcinoma

LU Hai_xia, FENG Zhen_bo, FENG Xiao_lan. Polymorphisms of CYP3A7 Gene of 210 Persons in Guangxi with Heavy Aflatoxin B1 Contamination[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(4): 292-294.

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Polymorphisms of CYP3A7 Gene of 210 Persons in Guangxi with Heavy Aflatoxin B1 Contamination

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