Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (5): 376-379.doi: 10.3969/j.issn.1004-616x.2008.05.010

Previous Articles     Next Articles

Adenine_induced Chronic Renal Function Impairment in Rats

ZHAO Hai_feng1,2, ZHANG Zhao_feng1, LI Qiong1, ZHAO Ming1, LI Yong1,   

  1. 1. Department of Nutrition and Food Hygiene， School of Public Health， Beijing University，Beijing 100083; 2. Department of Nutrition and Food Hygiene，School of Public Health，Shanxi Medical University，Taiyuan 030001，China
  • Received:2007-10-29 Revised:2007-12-26 Online:2008-09-30 Published:2008-09-30

PDF (PC)

2153

Abstract: BACKGROUND AND AIM: To make rats' chronic renal function impairment model through adenine induce. MATERIALS AND METHODS: 16 male SD rats were randomly divided into control group and renal function impairment model group. Distilled water was administered orally to rats in the control group and adenine suspension 100 mg/(kg·d) was given to establish the model of renal function impairment. The experiment lasted 12 weeks. Time_dependent changes in serum creatinine (Cr), urea nitrogen (BUN) levels and creatinine clearance rate (Ccr) were monitored. Renal morphological changes were examined. RESULTS: Cr, BUN levels in the model group were higher and Ccr was lower significantly than control group. Renal function impairment was aggravated with extended experimental time. Pathological and ultramicrostructural changes were observed. CONCLUSION: Chronic renal function impairment model in rats could be successfully induced by adenine suspension.

Key words: adenine, rat, in chronic renal function impairment, model