STAT3在人喉鳞状细胞癌中的表达及意义

doi:10.3969/j.issn.1004-616x.2010.02.008

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (2): 112-114.doi: 10.3969/j.issn.1004-616x.2010.02.008

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Expression and significance of STAT3 in laryngeal squamous cell cancer

FU Dong-na1;WEN Lian-ji2;GAO Li-fang3;ZHAO Yin2;WANG Shu-ying1;FENG Li1;QI Xiao-dan1

1.Department of Biochemistry and Molecular Biology, Qiqihar Medical College, Qiqihar 161006, Heilongjiang; 2. Department of Otorhinolaryngology, Second Hospital of Jilin University, Changchun 130041; 3. Cardiovascular Hospital of Jilin, Changchun 130062, Jilin, China

Received:2009-10-12 Revised:2009-11-18 Online:2010-03-30 Published:2010-03-30
Contact: WEN Lian-ji

Abstract

Abstract: OBJECTIVE: To explore the expression and significance of signal transducers and activators of transcription 3(STAT3) in laryngeal squamous cell cancer. METHODS: Immunohistochemical technique was used to examine expression of STAT3 in 12 normal tissues and 38 laryngeal cancer. RESULTS: Positive staining of STAT3 was localized in the cytoplasm. The positive rate of STAT3 in 38 laryngeal cancer was significantly higher than those in 12 normal tissues(P<0.01). Overexpression of STAT3 protein was tested in those cancers with lymph nodes metastasis(P<0.05), and had a close relationship with histological grades(P<0.05). CONCLUSION: Overexpression of STAT3 might have a close correlation with the development of laryngeal squamous cell carcinoma.

Key words: laryngeal neoplasms, carcinoma, signal transducers and activators of transcription 3

CLC Number:

R739.65

FU Dong-na, WEN Lian-ji, GAO Li-fang, ZHAO Yin, WANG Shu-ying, FENG Li, QI Xiao-dan. Expression and significance of STAT3 in laryngeal squamous cell cancer[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(2): 112-114.

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Expression and significance of STAT3 in laryngeal squamous cell cancer

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