淮河蚌埠段水中有机物对小鼠遗传毒性和脂质过氧化作用的影响

doi:10.3969/j.issn.1004-616x.2001.03.009

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (3): 163-165.doi: 10.3969/j.issn.1004-616x.2001.03.009

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EFFECTS OF ORGANIC CHEMICAL POLLUTANTS IN WATER FROM BENGBU SECTION OF HUAI RIVER ON MOUSE GENOTOXICITY AND LIPID PEROXIDATION

ZHUANG Ying, JIANG Cheng-mei, ZHAO Hong, WANG Bang-xia

Department of Public Health, Bengbu Medical College, Bengbu 233003, China

Received:1999-10-31 Revised:2001-02-01 Online:2001-07-30 Published:2001-07-30

Abstract

Abstract: Purpose : To investigate the effect s of organic chemical pollutant s in water f rom Bengbu (N) section of Huai river on mouse gentoxicity and lipid peroxidation. Methods : Organic chemical concent rates of water were taken f rom the lower and the upper N sections of Huai River , the water works , and the dist ribution network ,respectively , and the mouse micronucleus test , sperm deformity test were used to detect their gentoxicity. Lipid peroxides (L PO) , superoxide dismutase (SOD) and glutathione peroxidase ( GSH2Px) were also determined. Results : The positive mutagenicity to a certain degree was induced by the organic chemical concent rates of the water samples ( P < 0. 05～0. 01) , high levels of L PO and lower activities of SOD and GSH2Px were found. Conclusion : Organic chemical pollutant s of the water in the N section of Huai River have potential genotoxicity and influence on mouse lipid peroxidation.

Key words: water pollution, organic chemicals concent rate, genotoxicity, lipid peroxidation.

CLC Number:

R123. 3

ZHUANG Ying, JIANG Cheng-mei, ZHAO Hong, WANG Bang-xia. EFFECTS OF ORGANIC CHEMICAL POLLUTANTS IN WATER FROM BENGBU SECTION OF HUAI RIVER ON MOUSE GENOTOXICITY AND LIPID PEROXIDATION[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2001, 13(3): 163-165.

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EFFECTS OF ORGANIC CHEMICAL POLLUTANTS IN WATER FROM BENGBU SECTION OF HUAI RIVER ON MOUSE GENOTOXICITY AND LIPID PEROXIDATION

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