N-烟酰基-L-天门冬氨酸的致突变性检测

doi:10.3969/j.issn.1004-616x.2007.02.021

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (2): 152-154.doi: 10.3969/j.issn.1004-616x.2007.02.021

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Research of N-Nicotinyl-aspartic Acid Mutagenicity

LIU Xiao-qiu, GU Fei, WANG Rong-xian,LI Mei-jia, HAN Ying

Institute of Radiation Medicine, Chinese Academy of Medical Sciences , Peking Union Medical College,Tianjin 300192, China

Received:2006-03-06 Revised:2006-06-16 Online:2007-03-30 Published:2007-03-30
Contact: LIU Xiao-qiu

Abstract

Abstract: BACKGROUND ＆ AIM：To study the genotoxicity of N-Nicotinyl-aspartic acid. MATERIALS AND METHODS:The mutagenicity of N-Nicotinyl-aspartic acid was examined using Ames test, CHO cell chromosome aberration test and micronucleus test. RESULTS： No increase in the number of revertant colonies was found in the Ames test with and without S9 mixture. The micronucleus rates and chromosome aberration rates at all doses were not significantly different from the control group . CONCLUSION： Mutagenicity of N-Nicotinyl-aspartic acid was not observed in this study.

Key words: Ames test, micronucleus, chromosome aberration, N-Nicotinyl-aspartic acid

LIU Xiao-qiu, GU Fei, WANG Rong-xian, LI Mei-jia, HAN Ying. Research of N-Nicotinyl-aspartic Acid Mutagenicity[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(2): 152-154.

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Research of N-Nicotinyl-aspartic Acid Mutagenicity

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