Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (5): 304-305.doi: 10.3969/j.issn.1004-616x.1998.05.010

Previous Articles     Next Articles

EFFECT OF VITB6 ON FREQUENCY OF SISTER CHROMATID EXCHANGE ( SCE) IN VARIOUS CELLS BY USING IN VITRO AND IN VIVO ASSAY

Deng Lixia , Zheng Lukang , Zhang Qiao   

  1. L ab. of Genetic Toxicology , School of Public Heal th , S un Yat2Sen University of Medical Sciences , Guangz hou 　510089
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-09-30 Published:1998-09-30

PDF (PC)

3018

Abstract: The purpose of this paper is to study the effect of VitB6 on f requency of sister chromatid exchange (SCE) in cells f rom human and animals by using in Vitro and in Vivo assay. In vit ro assay , the frequency of SCE was markedly increased in both cells f rom human lymphocytes and the Chinese hamster lung cell line (CHL) , which were exposed to the VitB6 in various doses.A dose response was presented. But in Vivo assay , the statistic difference between the SCE rates of mouse bone marrow cells in test group and in that of cont rol group was not observed. In Vivo assay , it seems that the VitB6 may be not a muatgen.

Key words: Frequency of sister chromatid exchange, VitB6, In vit ro assay, In vivo assay