苜蓿总皂苷的急性毒性和遗传毒性

doi:10.3969/j.issn.1004-616x.2009.01.015

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2009, Vol. 21 ›› Issue (1): 62-064.doi: 10.3969/j.issn.1004-616x.2009.01.015

Previous Articles Next Articles

Acute Toxicity and the Genotoxicity of Alfalfa Total Saponins

LI Guo-feng, LI Lan-fang, ZHANG Qin-zeng,HAO Na, WANG Wei

Hebei Center for Disease Control and Prevention，Shijiazhuang 050021,China

Received:2008-08-27 Revised:2008-10-22 Online:2009-01-30 Published:2009-01-30

Abstract

Abstract: BACKGROUND AND AIM: To observe the acute toxicity and the genotoxicity of alfalfa total saponins(ATS). MATERIALS AND METHODS: Kunming mice were used to test the LD50 of ATS. The mouse bone marrow micronucleus test and the mouse sperm morphology test were used to evaluate genotoxicity of ATS. RESULTS: The LD50 of ATS was 13.01 g/kg, 95％ confidence interval was 12.46～13.58 g/kg. The micronucleus rates and sperm abnormality rates were negative. CONCLUSION: The ATS was considered a substance with no toxicity and genotoxicity in this study.

Key words: alfalfa total saponins, acute toxicity, micronucleus test, sperm abnormality

LI Guo-feng, LI Lan-fang, ZHANG Qin-zeng, HAO Na, WANG Wei. Acute Toxicity and the Genotoxicity of Alfalfa Total Saponins[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2009, 21(1): 62-064.

[1]	YANG Yu, HUANG Yali, LIN Fei, TANG Long. Acute toxicity and genotoxicity of antitumor serum thymic factor 9 peptide [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 57-61.
[2]	XIA Qiyue, YUE Qianlan, DOU Jiexiong, ZHUANG Siqi, LIU Keliang. Toxicological test of orally administered sodium sulfide in rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 62-66.
[3]	GE Xianmin, LI Bin, HUANG Chaopei, GAO Yuqiu, LUO Hailan, YANG Hui, WANG Yanwu, WEN Pingjing, LAN Guanghua, CHEN Huanhuan, MENG Qin, LUO Liuhong, DENG Yueqin, LIU Shuaifeng, WU Xiuling. Acute oral toxicity and mutagenicity of combined drugs for anti HIV [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 466-469,474.
[4]	CAI Qi, GAO Deyu, SHI Jianfeng, YU Hao, HAN Yan, YANG Liu, ZHAO Lei, WANG Zhaoxu. Potential use of tree shrew as an animal model for the micronucleus test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 370-374,382.
[5]	HUANG Chaopei, QIN Huiyan, ZHANG Lujuan, WANG Yanwu, HE Li, FU Weizhong. Study on acute toxicity and mutagenicity of Aronia melanocarpa extract in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 474-476.
[6]	CAO Yiyi, LIU Weiying, YOU Xinyue, XI Jing, Chen Ruixue, ZHANG Xinyu, LUAN Yang. In vitro genotoxicity evaluation of BDE-3, BDE-47 and BDE-209 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 15-20,28.
[7]	WANG Quankai, XIE Guangyun, MA Shunpeng, GUO Haoran, WUHAN Baolier, SONG Jiayang, XU Jianning. Genotoxicity evaluation of glycidyl methacrylate [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 479-482.
[8]	XIA Ying, FU Shaohua, ZHANG Yinjing, WANG Wei. Genetic toxicity test of a pesticide, Paichongding [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 136-139.
[9]	CAO Yiyi, XI Jing, TANG Weifeng, YOU Xinyue, LIU Weiying, LUAN Yang. Genotoxicity evaluation of triclosan in vitro [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(1): 71-75.
[10]	WANG Zhi, LING Xi, ZHANG Guowei, GAO Jianfang, ZOU Peng, JING Che, LIN Zhetao, LIU Jinyi, CAO Jia, AO Lin. Effect of folic acid on DNA demethylation and chromosomal damage in mice after their inhalation exposure to 1, 3-butadiene [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(3): 189-193.
[11]	CHEN Xiujuan, LIU Xiangmei, PANG Zengxiong, LIU Donghong, LIU Ying, LUO Xuelian, CHEN Hanjin, HUANG Yufeng. Acute and genetic toxicity of aqueous extract of Eriobotrya japonica leaves [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 403-406.
[12]	HAN Tianjiao, ZHOU Changhui, CHANG Yan. Establishment a method for genotoxicity evaluation of ethyl methanesulfonate in rats using Comet and flow micronucleus assays [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 277-280.
[13]	YING Jian, HAO Binxiu, MENG Qingjia, CHEN Ran, WANG Liming, WANG Chunling. Acute toxicity and genotoxicity of crude water extracts from tea mistletoe Viscum Liquidambaricolum Hayata [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 306-309,324.
[14]	LUO Xueting, CAI Qijun, ZHAO Bo, CHEN Weimin, CHEN Xiao, ZHANG Xiaowen. Evaluation of acute and genetic toxicity of Zihe herbal solid beverage in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 302-305.
[15]	SU Bin, FU Yong, HOU Xiaodong, ZHANG Chaoying, LIANG Hui. Toxicity evaluation of tobacco seed oil [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 60-65.

Acute Toxicity and the Genotoxicity of Alfalfa Total Saponins

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments