抗癌药物金克( Jinke) 对小鼠骨髓、脾脏细胞微核形成的效应

doi:10.3969/j.issn.1004-616x.2002.01.009

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (1): 27-029.doi: 10.3969/j.issn.1004-616x.2002.01.009

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EFFECT OF ANTICANCER DRUG JINKE ON MICRONUCLEUS FORMATION IN MOUSE SPLEEN AND BONE MARROW PCE CELLS

YE Ya-xin

Department of Biology , Suzhou Railway Teachers College , Suzhou 215009 , China

Received:2001-05-20 Revised:2001-08-06 Online:2002-01-30 Published:2002-01-30
Contact: YE Ya-xin

Abstract

Abstract: Purpose : To investigate the mutagenic effects of anticancer drug Jinke. Methods : micronucleus test in mice and bone marrow PCE cells were used respectively to determine micronucleul cell frequencies (MNCF) . Results : The MNCF of Jinke-treated groups were much significantly higher than that of control group , and to some extent , were dose-responsive. Conclusion : Jinke has strong mutagenic effect , and the result of micronucleus test on spleen PCE cells is closely similar to that on bone marrow cells.

Key words: micronucleus test, Jinke, spleen, bone marrow

CLC Number:

R979. 1

YE Ya-xin. EFFECT OF ANTICANCER DRUG JINKE ON MICRONUCLEUS FORMATION IN MOUSE SPLEEN AND BONE MARROW PCE CELLS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(1): 27-029.

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EFFECT OF ANTICANCER DRUG JINKE ON MICRONUCLEUS FORMATION IN MOUSE SPLEEN AND BONE MARROW PCE CELLS

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