Abstract:

OBJECTIVE: To study the function of Yu-mu-li-sheng-ru-ling capsule in milk secretion in rats. METHODS：SD rats with overload lactation model were used. The pregnant rats were randomly divided into four groups，including test groups with different dosage (1 800，900，450 mg/kg) and negative control group. The mother rats  were gavaged for 25 d continuously during lactation. Body weight of mother and baby rats，survival ratio of baby rats and breast tissue pathology examination of mother rats were evaluated. RESULTS：No significant differences were observed in body weight of  treated  mother rats. For 450 and 900 mg/kg groups，baby rat survival ratios were 89%-94%，average body weight was insignificantly increased compared with that in negative control group(P>0.05). For 1 800 mg/kg group，baby rat survival ratio was 100%，average body weight increased significantly during early and late stage of lactation (P<0.05). Increased milk in breast tissue，filled acinus cavities and expanded mammary gland tubes were obviously observed. CONCLUSION： At 10 times  higher  than clinical dosage (1 800 mg/kg)，Sheng-ru-ling capsule could facilitate milk secretion in lactating rats，increase baby rat body weight and reduce malnutrition death.

Key words: facilitating milk secretion, overload lactation, rat, Yu-mu-li-sheng-ru-ling capsule