Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (6): 456-458.doi: 10.3969/j.issn.1004-616x.2008.06.010

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Red Blood C3b Receptor and Ratio of CD4＋/CD8＋ and NK Cell Activity in Gastric Cardia Carcinoma and Gastric Cancer Patients

LIANG Suo-yuan, SHAN Bao-en, BAI Yin-miao，WU Li-hua, AI Jun   

  1. Cancer Institute of Hebei Province ,the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011 , Hebei, China
  • Received:2008-01-03 Revised:2008-09-04 Online:2008-11-30 Published:2008-11-30

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Abstract: BACKGROUND AND AIM: To investigate the correlation between red blood C3b receptor (RBC-C3bR) and lymphocytic cell (TC) immune function in tumor patients. MATERIALS AND METHODS: RBC-C3bR, natural killer (NK) cell activity and T lymphocyte subsets of 53 patients with gastric cardia carcinoma, 51 gastric cancer and 30 healthy controls were measured by microzyme garland test , MTT-assay and monoclonal anti-human T lymphocyte antibody. RESULTS: Compared with the control group, RBC-C3bR , NK cell activity, CD3＋, CD4＋,CD4＋/CD8＋ ratio were significantly decreased in tumor patients (F=28.68 ，P<0.01). Positive correlations were observed between RBC-C3bR with both NK cell activity and CD4＋/CD8＋ ratio (gastric cardia carcinoma RBC-C3bR and CD4＋/CD8＋ ratio: r=0.431, P<0.01; RBC-C3bR and NK cell activity：r=0.347,P<0.05; gastric cancer RBC-C3bR and CD4＋/CD8＋ ratio: r=0.429, P<0.01; RBC-C3bR and NK cell activity,r=0.528, P<0.01). CONCLUSION: The immune funtion of erythrocytes was inhibited same as lymphocytes and there was close relationship between them in gastric cardia carcinoma, gastric cancer patients.

Key words: gastric cardia carcinoma, gastric cancer, RBC-C3bR, lymphocyte subsets, NK cell