Carcinogenesis, Teratogenesis & Mutagenesis ›› 2023, Vol. 35 ›› Issue (5): 382-386.doi: 10.3969/j.issn.1004-616x.2023.05.009

Previous Articles     Next Articles

Analysis of high-risk HPV infection results in Handan

DONG Zhiling1, WANG Zhigang1, YAO Li1, CHEN Chaoying2, HU Min3, WANG Lei1   

  1. 1. Handan Central Hospital, Handan 056002;
    2. Handan Hospital of Integrated Chinese and Western Medicine, Handan 056005;
    3. Xinxing Hospital Area of Handan Central Hospital, Handan 056300, Hebei, China
  • Received:2023-05-11 Revised:2023-09-20 Published:2023-10-13

PDF (PC)

156

Abstract: OBJECTIVE:To analyze the prevalence,age distribution and annual infection trend of 17 high-risk HPV subtypes in Handan. METHODS: The high-risk HPV results of 64 317 female patients who came to Handan Central Hospital for cervical cancer screening from January 1,2014 to December 31,2021 were collected. The overall prevalence, distribution types, age-specific prevalence and annual trends were analyzed. RESULTS: Among 64 137 female patients screened for cervical cancer,16 096 were positive for high-risk HPV, with an overall high-risk infection rate of 25.1%, with 11 902(73.9%) of single type infection,and 4 194(26.1%) of double or more types of multiple infection. The top five subtypes of infection rate were HPV16,HPV52,HPV58,HPV53 and HPV51,accounting for 16.5%,14.5%,10.5%,7.9% and 7.2% of the positive items respectively. The highest infection rate of high-risk HPV was ≤ 20 years old,with the infection rate of 70.6%,followed by ≥ 60 years old,with the infection rate constituent ratio of 29.4%. The age group with the highest infection rate of single high-risk HPV was 41-50 years old, and the constituent ratio of infection rate was 77.8%. The age group with the highest infection rate of multiple severe high-risk HPV in each age group was ≤ 20 years old,and the constituent ratio of infection rate was 39.1%. The infection rate of single high-risk HPV and multiple severe high-risk HPV in each age group was statistically different (P<0.01). The annual high risk HPV infection rate showed a downward trend (P<0.01). CONCLUSION: The infection rate of high-risk HPV among women in Handan was high. The common subtypes of high-risk HPV infection were HPV16,HPV52,HPV58,HPV53,and HPV51.And the distribution was U-shaped with age.According to the analysis,the annual infection rate showed a downward trend from 2014 to 2021. The prevalent characteristics of HPV should help to guide HPV vaccinations and cervical cancer screenings.

Key words: human papillomavirus, cervical cancer screening, genotype, annual trend

CLC Number: