Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (3): 162-163.doi: 10.3969/j.issn.1004-616x.2000.03.011

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ACUTE TOXIC AND MUTAGENIC EFFECTS OF THE ACROSIN INHIBITOR KF - 950

ZHAO Ya-nan , SHENG Yi , JI Ya-zhong , et al   

  1. Reproduction Research Center of PL A , Changhai Hospital , S hanghai  200433 , China
  • Received:1999-09-05 Revised:1999-12-20 Online:2000-07-30 Published:2000-07-30

Abstract: Purpose and Methods : The acute toxic and mutagenic effect s of acrosin inhibitor KF - 950 were evaluated in mice and Ames assay. Results and Conclusion : Half lethal dosage of KF - 950 in mice was more than 5 000mg/ kg. The mutagenic activity of KF - 950 , under the doses used , was not observed in TA97 , TA98 , TA100 ,TA102 ,with or without S9 activitor.

Key words: acrosin inhibitor, acute toxicity, mutagenesis

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