Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (3): 168-170.doi: 10.3969/j.issn.1004-616x.2003.03.012

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A COMPARISON OF NATURAL MICRONUCLEUS FREQUENCIES IN POLYCHROMATIC ERYTHROCYTES BETWEEN KUNMING MICE AND NIH MICE

LI Xin, LIANG Xue-mei, ZHANG Jing, et al   

  1. Lab of Genetic Toxicology, Center of Disease Control and Prevention of Guangdong Province, Guangzhou 510300, China
  • Received:2002-08-29 Revised:2002-12-26 Online:2003-07-30 Published:2003-07-30
  • Contact: LI Xin

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Abstract: Purpose: To compare natural micronucleus frequencies in polychromatic erythrocytes (fMPCE) from normal Kunming mouse chest bone marrow to that from normal NIH strain. Methods: According to Procedures and methods for toxicological assessment on food safety, 30 h micronucleus test was performed, the numbers of micronuclei were scored, and the fMPCE was calculated. Results: The natural fMPCE from the chest bone marrow showed skew distribution, and the media was a good indicator. The natural fMPCE of Kunming mice was 1.0 (0, 4.0) in female, and 2.0 (0, 6.0) in male, and there was a significant difference between different sex (P<0.05). The natural fMPCE of NIH mice was 2.0 (0, 4.0) in female, 2.0 (0, 6.0) in male, and there was no significant difference between different sex. There was no significant difference between Kunming and NIH mice in the natural fMPCE. Conclusion: The natural fMPCE from chest bone marrow of Kunming mice and NIH mice are similar. There is no significant difference between two strains; but a significant difference between different sex in Kunming mice does exist (P<0.05).

Key words: micronucleus, kunming mouse, NIH mouse