Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (4): 247-248.doi: 10.3969/j.issn.1004-616x.2004.04.020

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Significance of Testing Ag-NORs in Periopheral Blood T Lymphocyte on Tumor Surveillance

JIANG You-hong,SUI Cheng-guang,MENG Fan-dong , et al   

  1. Institute of Cancer Research of the First Affiliated Hospital of China Medical University,Shenyang 110001,China
  • Received:2003-12-08 Revised:2004-03-02 Online:2004-07-30 Published:2004-07-30
  • Contact: JIANG You-hong

Abstract: BACKGROUND & ATM: To provide a scientific method of evaluating the tumor patients' prognosis and the assistant diagnosis by analyzing patients' immunocompetence by quantitating the Ag-NORs in periopheral blood T lymphocyte. MATERIAL AND METHODS:Quantitive analysis of the Ag-NORs in periopheral blood T lymphocyte was performed at the gene transcription level with the KL-immunological analysis system, using the ratio between the surface areas of silver-dyed and the nucleus(I.S %)as the index to reflects the rDNA transcription activity.RESULTS:Significant difference was found between the values of the I.S% in malignant tumor patients and in health persons. The values of the I.S% in tumor patients were much lower than that of the health persons.No statistical difference was found between the values of the I.S% in all kinds of malignant tumor patients that we studied. CONCLUSION:Testing Ag-NORs in periopheral blood T lymphocyte has the important significance to distinguish the malignant tumor patients from the health persons,but it can't distinguish between all kinds of malignant tumors.

Key words: Ag-NORs, T lymphocyte, I.S%, KL-immunological analysis system