基于多倍体肿瘤巨细胞的抗肿瘤研究进展

doi:10.3969/j.issn.1004-616x.2024.04.014

摘要/Abstract

摘要： 肿瘤研究的不断深入揭示了肿瘤细胞的多样性和复杂性。研究表明，当肿瘤细胞受到放疗、化疗或缺氧等刺激后，可以形成多倍体肿瘤巨细胞(PGCC)以抵抗外界生存胁迫，PGCC在一段时期的休眠后，可重新恢复增殖。相较于正常二倍体肿瘤细胞，PGCC具有更强的成瘤能力、侵袭转移能力和耐药性，可以促进肿瘤的发生发展、侵袭转移，驱动肿瘤复发，是肿瘤获得异质性的重要来源，是一种十分恶性的肿瘤细胞亚群。近年来基于对PGCC在肿瘤发生发展及治疗中重要作用的认识，有研究者提出一些具有潜力的抗肿瘤治疗方案。本文就PGCC的生物学特征、形成机制，其对微环境的高耐受性、对肿瘤发展的影响，以及针对PGCC的治疗方案等方面的研究作一综述。

关键词: 多倍体肿瘤巨细胞, 抗肿瘤, 癌症干细胞, 耐药

中图分类号:

R730.2

李子烜, 孙震晓. 基于多倍体肿瘤巨细胞的抗肿瘤研究进展[J]. 癌变·畸变·突变, 2024, 36(4): 325-327,333.

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