GSTM1 多态性与肺癌敏感性关系研究

doi:10.3969/j.issn.1004-616x.1998.03.006

癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (3): 149-151.doi: 10.3969/j.issn.1004-616x.1998.03.006

GSTM1 多态性与肺癌敏感性关系研究

高坚瑞1 　张　桥2

1江苏镇江医学院卫生学教研室　镇江　212001 2中山医科大学公共卫生学院分子毒理研究室　广州　510089

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-05-30 发布日期:1998-05-30

STUDY ON THE RELATIONSHIP BETWEEN GSTM1 POLYMORPHISM AND LUNG CANCER SUSCEPTIBILITY

Gao Jianriu1 ,Zhang Qiao2

1Zhen Jiang Medical College Department of Hygiene Zhenjiang , Jiangsu Province , Zhenjiang 212001 2Sen Yat2Sen University of Medical Science , School of Public Heal th Morlecular Toxicology Unit , Guangz hou 510089

Received:1900-01-01 Revised:1900-01-01 Online:1998-05-30 Published:1998-05-30

摘要/Abstract

摘要： GSTM1 与进入体内的环境化学致癌物代谢降解有关,人群中GSTM1 表现出多态生,不同种族、不同个体代谢降解环境化学物的能力差异很大,这可能是个体间对环境致癌物暴露反应不同的原因。探讨GSTM1 遗传多态性与肺癌敏感性关系,筛检高危人群,为肺癌防治提供理论依据,我们研究了GSTM1 多态性在广东籍肺癌病人和健康对照组中的分布状况。结果显示GSTM1 缺陷型( GSTM1 0/ 0) 在肺癌病人中频率明显增加。提示GSTM1 遗传多态性可能与肺癌敏感性有关。

关键词: GSTM1, 遗传多态性, 肺癌敏感性

Abstract: GSTM1 is relevant degradation of environmental carcinogens entered body. Among the population with variant genetic polymorphism of GSTM1 ,may rendered variant response to expoure of environmental chemical carcinogens and result in various susceptibility. In order to study the relationship between GSTM1 polymorphism and lung cancer susceptibility ,we have examined the dist ribution of GSTM1 genetic polymorphism in lung cancer patient s and health cont rol who are native Gangdong Chinese. Result have shown that f requenty of GSTM10/ 0 genotype is significantly high in lung cancer patient s . It is suggested that there is a relationship between GSTM1 genotype and lung cancer susceptibility.

Key words: GSTM1, Genetic Polymorphism, Lung Cancer Susceptibility

高坚瑞　张　桥. GSTM1 多态性与肺癌敏感性关系研究[J]. 癌变·畸变·突变, 1998, 10(3): 149-151.

Gao Jianriu , Zhang Qiao. STUDY ON THE RELATIONSHIP BETWEEN GSTM1 POLYMORPHISM AND LUNG CANCER SUSCEPTIBILITY[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(3): 149-151.

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GSTM1 多态性与肺癌敏感性关系研究

STUDY ON THE RELATIONSHIP BETWEEN GSTM1 POLYMORPHISM AND LUNG CANCER SUSCEPTIBILITY

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