癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (4): 236-238.doi: 10.3969/j.issn.1004-616x.1998.04.011

• 论著 • 上一篇    下一篇

N - 乙酰化酶多态性与胃癌关系的研究

陈　华1 　张一帆2 　许东坡2 　张祥福3 　孙昌盛1   

  1. 1福建医科大学预防医学系　福州　350004 　　2 福建医科大学附属第一医院　3 福建医科大学附属协和医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-07-30 发布日期:1998-07-30

STUDY ON THE ASSOCIATION OF THE N - ACETYLTRANSFERASE POLYMORPLISM WITH GASTRIC CANCER

Chen H , Zhang YF , Xu DP , Zhang XF , Sun CS   

  1. Fujian Madical Univercity , Fuz hou 　350004Abstract 　Polymorphism of metabalic enzyme is one of the factors relevant to the susceptibility to
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-07-30 Published:1998-07-30

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摘要： 代谢酶多态性决定着机体对外源化学物的易感性和耐受性,也是肿瘤发生的遗传易感影响因素之一。本文报道了胃癌病人中N - 乙酰化酶多态性的调研。34 例胃癌病人中13 例为慢型(38124 %) ;对照组107人中20 人为慢型(18169 %) 。基因频率分别016183 和014323 ,两者之间有显著差异( P = 0. 022) 。从中推算出乙酰化酶慢型者患胃癌的相对危险度为2169 (1116～6. 27) ,说明乙酰化酰慢型作为肿瘤遗传易感因素,在胃癌发病中的作用不应忽视。

关键词: N - 乙酰化酶多态性, 肿瘤遗传易感性, 胃癌

Abstract: Polymorphism of metabalic enzyme is one of the factors relevant to the susceptibility to environmental chemicals and heredicary predispositional to carcinogenesis. The polymorphism of N - acetylt ransferase among gast ric cancers is investigated and reported. It was found that 13 among 34 GC patient s (38. 24 %) were slow type of N - AT versus the referring figure 20/ 107 (18. 69 %) in the cont rols. Their gene f requencies were calculated as 0. 6183 and 0. 4323 respec tively , the difference was statistically significant ( P = 0. 022) . The OR of GC for slow N2AT was 2. 69 (1. 16 - 6. 27) , suggesting that slow N2AT should be considered as one possible aetiological factor of GC.

Key words: N-acetylt ransferase polymorphism, Genetic predispostion, Gastic cancer

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