癌变·畸变·突变 ›› 2006, Vol. 18 ›› Issue (1): 68-070.doi: 10.3969/j.issn.1004-616x.2006.01.020

• 检测研究 • 上一篇    下一篇

伪麻黄碱对大鼠的致畸作用

孙晓英;张振军;边学峰;陈 庆;于 燕   

  1. 西安交通大学医学院环境卫生学教研室，陕西 西安 710061
  • 收稿日期:2005-03-14 修回日期:2005-05-23 出版日期:2006-01-30 发布日期:2006-01-30
  • 通讯作者: 张振军

Study on the Teratogenic Effects of Pseudoephedrine in Rats

SUN Xiao-ying;ZHANG Zhen-jun; BIAN Xue-feng;CHEN Qing;YU Yan   

  1. Department of Environmental Health, Xi’an Jiaotong University, Xi’an 710061, China
  • Received:2005-03-14 Revised:2005-05-23 Online:2006-01-30 Published:2006-01-30
  • Contact: ZHANG Zhen－jun

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摘要： 背景与目的：研究伪麻黄碱对大鼠的致畸作用，为其应用提供毒理学安全依据。材料与方法：将Sprague-Dawley孕鼠随机分为4组，即伪麻黄碱高、中、低3个剂量组和阴性对照组。分别经口给予伪麻黄碱50、100、200 mg/kg和生理盐水，进行传统的致畸实验，观察母鼠及胎仔的情况。结果：伪麻黄碱高剂量组孕鼠的总增重、死胎数和胎仔体重与阴性对照组比较差异有统计学意义（P<0.05）。各剂量组孕鼠的生殖能力和胎仔畸形情况与对照组相比差异无统计学意义(P>0.05)。结论：在实验剂量范围内，伪麻黄碱对大鼠有一定的母体毒性和胚胎毒性。

关键词: 伪麻黄碱, 大鼠, 致畸作用

Abstract: BACKGROUND & AIM: This study was undertaken to determine the potentially teratogenic effects of Pseudoephedrine to SD rats and to provide toxicological information. MATERIAL AND METHODS: SD pregnant rats were randomly divided into four groups: Pseudoephedrine 50、100、200 mg/kg and negative control. Conventional teratogenicity test was performed. Female rats was given Pseudoephedrine by gastric intubation at 50,100,200 mg/kg on days 6~15 of gestation. RESULTS: Adjusted weight gain of pregnant rats and body weight of fetuses were comparable to the control at 200 mg/kg. The incidence of dead rats was significantly increased at 200 mg/kg. CONCLUSION: Among the range of experiment doses, Pseudoephedrine was considered to have a maternal toxicity, embryo toxicity and teratogenic effects in SD rats.

Key words: Pseudoephedrine, rats, teratogenicity

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