癌变·畸变·突变 ›› 2007, Vol. 19 ›› Issue (1): 44-046.doi: 10.3969/j.issn.1004-616x.2007.01.013

• 论著 • 上一篇    下一篇

河南林县居民粮食中互隔交链孢霉及其毒素污染和人群暴露状况研究

杨胜利；董子明；裴留成；丁兰平；张慧芳；宋爱云；宫亚欧；刘桂亭；薛乐勋   

  1. 郑州大学基础医学院，郑州　450052
  • 收稿日期:2006-01-18 修回日期:2006-08-16 出版日期:2007-01-30 发布日期:2007-01-30

Study on Contamination of Alternaria Alternata in Grains and Exposure to Its Toxins in Residents from Henan Linxian

YANG Sheng-li,DONG Zi-ming, PEI Liu-cheng, DING Lan-ping, ZHANG Hui-fang, SONG Ai-yun, GONG Ya-ou, LIU Gui-ting, XUE Le-xun   

  1. College of Basic Medical Sciences Zhengzhou University, Zhengzhou 450052，China
  • Received:2006-01-18 Revised:2006-08-16 Online:2007-01-30 Published:2007-01-30
  • Contact: XUE Le-xun

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摘要： 背景与目的： 调查林县居民粮食中互隔交链孢霉(Alternaria alternata)污染情况及人群中互隔交链孢霉有关毒素-交链孢酚(Alternariol, AOH)和交链孢酚单甲醚 (alternariol monomethyl ether, AME)暴露水平，探讨互隔交链孢霉毒素污染与林县食管癌发生的关系。 材料与方法： 对林县居民粮食及尿样中互隔交链孢霉做分离培养, 采用薄层层析(TLC)法检测AOH和AME，并与本室10年前相应检测结果比较。 结果： ① 2004年小麦中互隔交链孢霉污染率与1981年相比差异具有统计学意义(χ2=359.283，P<0.01)。②2004年小麦中AOH阳性率低于1995年(χ2=5.152，P<0.05)。③2004年小麦面粉中AOH阳性率低于小麦原粮(χ2=5.128，P<0.05)。④ 2004年99份尿液中4份AOH阳性，1份AME阳性，明显低于1992年检测结果，其差异均有统计学意义(χ2=7.082， P<0.01;χ2=14.282，P<0.01)。结论: 2004年河南林县居民粮食中互隔交链孢霉及其相关毒素污染状况有不同程度的减轻。此与当地食管癌发生率的降低可能有一定的关系。

关键词: 林县, 粮食, 互隔交链孢霉, 交链孢酚, 交链孢酚单甲醚

Abstract: BACKGROUND ＆ AIM: To investigate the relationship between the toxins of Alternaria alternata and the incidence of esoghageal cancer in Linxian. MATERIALS AND METHODS: Alternaria alternata was isolated from grains in Linxian and its toxins from grains and urine from residents in Linxian were examined by the thin-layer chromatography, and results were compared with previous measured levels. RESULTS: ①the rate of contamination by Alternaria alternata in wheat was less than that in 1981 (χ2=359.283，P<0.01). ② the positive rate of AOH in wheat in 2004 were lower than those in 1995 (χ2=5.152，P<0.05). ③the positive rate of AOH in the wheat flour was lower than those in grain (χ2=5.128，P<0.05). ④ 4 out of 99 samples of urine contained AOH ,and 1 of these had AME in 2004. The results were all lower than those in 1992, (χ2=7.082，P<0.01; χ2=14.282,P<0.01 respectively). CONCLUSION: There is an association between the decrease in exposure to the toxins of Alternaria alternata and the lowered incidence of esophageal cancer in local residents.

Key words: Linxian, grains, alternaria alternata, alternariol, alternariol monomethyl ether

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