癌变·畸变·突变 ›› 2007, Vol. 19 ›› Issue (1): 47-049.doi: 10.3969/j.issn.1004-616x.2007.01.014

• 论著 • 上一篇    下一篇

1，2-二甲基-3-羟基-4-吡啶酮遗传毒性的研究

吴世德1；刘　萍2,；冯国昌2；禚金花2；姚玉娜2   

  1. 1.山东省生物药物研究院，山东　济南　250014；2.山东大学公共卫生学院卫生检验所，山东　济南　250012
  • 收稿日期:2006-02-15 修回日期:2006-05-30 出版日期:2007-01-30 发布日期:2007-01-30

Preliminary Study of Inheritable Toxicity of 1,2-dimethyl-3- hydroxypyrid-4-one in Mice

WU Shi-de1,LIU Ping2,,FENG Guo-chang2，ZHUO Jin-hua2,YAO Yu-na2   

  1. 1.Institute of Shandong Biological Medicines,Jinan 250014, China; 2.Department of Health Surveillance, College of Public Health,Shandong University,Jinan 250012, China
  • Received:2006-02-15 Revised:2006-05-30 Online:2007-01-30 Published:2007-01-30

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摘要： 背景与目的： 研究1，2-二甲基-3-羟基-4-吡啶酮(DHPO)的急性毒性及不同剂量、不同时间的遗传毒性。 材料与方法： 采用昆明种小鼠，先进行LD50试验，然后对高(1/2 LD50)、中(1/4 LD50)、低(1/8 LD50)DHPO剂量组进行外周血和骨髓微核率的观察。结果： DHPO的小鼠经口LD50为562.34 mg/kg。外周血和骨髓微核试验显示，1/8 LD50(70 mg/kg)组、1/4 LD50(140 mg/kg)组微核率与阴性对照组相比差异均无统计学意义(P>0.05)；1/2 LD50(280 mg/kg)组微核率高于阴性对照组、1/8 LD50(140 mg/kg)组和1/4 LD50组(P均<0.05)。 结论： DHPO属于低毒药物，具有小鼠体内染色体畸变的遗传毒性。

关键词: 1, 2-二甲基-3-羟基-4-吡啶酮, LD50, 骨髓多染红细胞, 微核试验

Abstract: BACKGROUND ＆ AIM: To investigate the acute toxicity and the inheritable toxicity of 1,2-dimethyl-3- hydroxypyrid-4-one(DHPO) in mice. MATERIALS AND METHODS: LD50 test was performed ,then Kun Ming mice were given different oral doses of the DHPO to carry out the micronucleus test under low(1/8 LD50), mid (1/4 LD50), high(1/2 LD50) doses. RESULTS: LD50 of DHPO was 562.34 mg/kg peroral in mice. 1/2 LD50 group was different from the negative control in the micronucleus test(P<0.05), whereas no significant differences were observed among 1/4 LD50 , 1/8 LD50 groups and negative control(P>0.05). CONCLUSION: Our results suggested that DHPO had low toxicity but had inheritable toxicity to a certain extent.

Key words: DHPO, LD50, polychromatic erythrocyte, micronucleus test

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