关键词: 1-氯甲基杂氮硅三环, 大鼠, 致畸

Abstract: BACKGROUND AND AIM: To investigate the teratogenicity of 1-chloromethylsilatrane in rats. MATERIALS AND METHODS: SD rats divided into 5 groups. On day 6-15 of gestation, SD rats received the test material at three doses of 10.29, 32.54 and 102.89 mg/kg by gavage. And at the same time, 2 similar group were dosed with 3％ starch paste (solvent control) and N,N'-methylene-bis-(α-amino-1,3,4-thiadiazole) (MATDA) (positive control). On day 20 of gestation, all rats were sacrificed. Body weight and observation data were collected during the study. RESULTS: The fetal skeletal abnormalities increased in groups treated with 32.54 and 102.89 mg/kg, showing sternum abnormalities with dysostosis, absent and abnormal ossification. The minimum teratogenic dose was 32.54 mg/kg. The body weight and fetal toxicity of pregnant rats were not different in treated groups compared with the control group. No abnormality was observed in growth effect, morphology and internal organs in rat fetuses in any group. CONCLUSION: Under this experimental condition, 1-chloromethylsilatrane had teratogenic toxicity on SD rats when given at certain dose.

Key words: 1-chloromethylsilatrane, rat, teratogenicity