双核细胞中核质桥和核芽的形成及其影响因素

doi:10.3969/j.issn.1004-616x.2013.01.016

摘要/Abstract

摘要：

胞质分裂阻滞法 (cytokinesis-block micronucleus，CBMN)主要用来分析双核细胞中的微核，研究发现该方法还可以分析其他指标，如核质桥和核芽等。目前核质桥 (nucleoplasmic bridge，NPB)及核芽 (nuclear bud，NBD) 分析是细胞组学分析的重要组成部分。NPB和NBD的形成受到许多因素的影响，而且有望成为新的辐射损伤生物标志物。本文将对NPB和NBD的定义、形态特征、形成机制及影响因素等方面进行综述。

关键词: 核质桥, 核芽, 电离辐射, 染色体损伤, 胞质分裂阻滞法, 毒理基因组学

赵骅,刘青杰. 双核细胞中核质桥和核芽的形成及其影响因素[J]. 癌变·畸变·突变, doi: 10.3969/j.issn.1004-616x.2013.01.016.

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