癌变·畸变·突变 ›› 2017, Vol. 29 ›› Issue (3): 230-234.doi: 10.3969/j.issn.1004-616x.2017.03.014

• 检测研究 • 上一篇    下一篇

胃癌患者血浆某些化学元素含量的病例对照研究

刘福志1, 李宏图1, 吴传城1, 蔡爱兰2, 陈昱1, 刘宝英1   

  1. 1. 福建医科大学公共卫生学院, 福建 福州350108;
    2. 福建省莆田市仙游县卫生计划生育局, 福建 仙游 351200
  • 收稿日期:2016-12-01 修回日期:2017-02-27 出版日期:2017-05-31 发布日期:2017-05-31
  • 通讯作者: 吴传城,E-mail:78926674@qq.com E-mail:78926674@qq.com
  • 作者简介:刘福志,E-mail:295320152@qq.com。
  • 基金资助:
    福建省仙游县消化道肿瘤病因学、流行病学研究项目(2013 B008);福建省自然科学基金(2015J01673,2017J01811)

A case control study on presence of chemical elements in plasma of gastric cancer patients

LIU Fuzhi1, LI Hongtu1, WU Chuancheng1, CAI Ailan2, CHEN Yu1, LIU Baoying1   

  1. 1. School of Public Health, Fujian Medical University, Fuzhou 350108;
    2. Health and Family Planning Bureau, Xianyou 351200, Fujian, China
  • Received:2016-12-01 Revised:2017-02-27 Online:2017-05-31 Published:2017-05-31

摘要: 目的:通过病例对照研究分析胃癌患者与健康人群血浆某些化学元素的差异及其与胃癌的关系。方法:采用成组病例对照研究方法,收集在仙游县本地居住10年以上,并经病理确诊的新发胃癌病例共299例,胃癌死亡率相近居住地的健康对照295例。通过问卷调查及血样采集等方式获取病例及对照组的一般情况、生活习惯等信息,运用微波消解法处理血样,电感耦合等离子体质谱法检测血浆化学元素。运用非参数检验比较两组人群血浆中化学元素含量的差异。结果:血浆化学元素在病例组和对照组中存在差异,病例组中铜(Cu)、镁(Mg)和Cu/锌(Zn)高于对照组(P < 0.01),病例组中钼(Mo)和钙(Ca)低于对照组(P < 0.01);通过多因素分析发现血浆Cu(OR=2.71)、Mg(OR=2.26)、Cu/Zn(OR=3.88)增加胃癌发病的风险,Mo(OR=0.48)、Ca(OR=0.7)减少胃癌发病的风险(P均 < 0.05)。结论:胃癌患者血浆某些化学元素水平较正常人群有显著变化。

关键词: 化学元素, 胃癌, 病例对照, 血浆

Abstract: OBJECTIVE:To compare the presence of chemical elements in plasma between gastric cancer patients and healthy people. METHODS:Using a case-control design,we focused on people who had lived in Xianyou for 10 years or more. Among them,we identified newly discovered cases of pathologically confirmed gastric cancer (299 cases) and 295 health cases. Among these cases,we obtained general situation information,living habits,etc. using questionnaires and collected blood samples. Blood samples were subjected to microwave digestion and chemical elements in plasma were analyzed by inductively coupled plasma mass spectrometry. The presence of chemical elements between the two groups were compared using non-parametric tests. RESULTS:Cu,Mg,and Cu/Zn in the case group were significantly higher than that in the control (P < 0.01). However,Mo,Ca in the case group were significantly lower (P < 0.01). Multivariate analysis showed that Cu (OR=2.71),Mg (OR=2.26),Cu/Zn (OR=3.88) were significantly associated with increased risk for gastric cancer but Mo (OR=0.48),Ca (OR=0.17) with significantly reduced risk. CONCLUSION:Levels of some plasma chemical elements in gastric cancer patients were significantly different from that of the normal population.

Key words: chemical element, gastric cancer, case control, plasma

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