线粒体在炎症调控中的作用研究进展

doi:10.3969/j.issn.1004-616x.2017.06.012

摘要/Abstract

摘要： 炎症反应与生命过程密切相关，不仅担当机体重要的"安全卫士"，也是引起绝大多数疾病的"罪魁祸首"。炎症相关的急慢性疾病是临床病例的主要来源，然而由于炎症分子通路复杂，且具体机制尚未阐明，导致炎性相关疾病缺乏有效救治措施，给患者造成沉重的身心伤害和医疗费用负担。大量研究表明，线粒体与多种炎症信号密不可分，是调控机体炎症发生和发展的关键。本文综述了炎症过程中线粒体的改变及其参与炎症调控机制的研究进展，以期为炎症相关疾病的防治提供新的策略和潜在靶点。

关键词: 线粒体, 炎症, 凋控机制, 自噬, 免疫细胞

中图分类号:

R364.5

韩孝先, 刘泽宇, 周庆彪, 张晓迪, 孔德钦, 海春旭, 于卫华. 线粒体在炎症调控中的作用研究进展[J]. 癌变·畸变·突变, 2017, 29(6): 467-470,475.

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