亚硝胺及前体化合物的致癌效应及其食用安全性研究进展

doi:10.3969/j.issn.1004-616x.2018.01.015

癌变·畸变·突变 ›› 2018, Vol. 30 ›› Issue (1): 76-79.doi: 10.3969/j.issn.1004-616x.2018.01.015

• 综述 • 上一篇

亚硝胺及前体化合物的致癌效应及其食用安全性研究进展

徐淼¹, 张倩男², 杨辉², 张立实¹, 贾旭东²

1. 四川大学华西公共卫生学院, 四川成都 610041;
2. 卫生部食品安全风险评估重点实验室, 国家食品安全风险评估中心, 北京 100021

收稿日期:2017-05-03 修回日期:2017-10-06 出版日期:2018-01-30 发布日期:2018-01-30
通讯作者: 杨辉,E-mail:yanghui@cfsa.net.cn;贾旭东,E-mail:jiaxudong@cfsa.net.cn E-mail:yanghui@cfsa.net.cn;jiaxudong@cfsa.net.cn
作者简介:徐淼,E-mail:xumiao1726@qq.com。
基金资助:
国家自然科学基金（81402679）

Received:2017-05-03 Revised:2017-10-06 Online:2018-01-30 Published:2018-01-30

摘要/Abstract

摘要： 亚硝胺是环境中最常见的一类化学致癌物，在食物、饮用水、烟草、酒精饮料、化妆品中广泛存在。亚硝酸盐和硝酸盐作为食品添加剂的广泛使用可能使亚硝胺的人体内暴露水平潜在增加。亚硝胺能够在不同种属动物中诱发肿瘤，但目前人体研究资料不足。亚硝胺的致癌作用机制除造成DNA损伤、修复无效致体细胞突变等传统认识之外，新的研究还着眼于炎症微环境塑造及其与机体免疫系统的相互作用。本文综述了食源性亚硝胺及其前体化合物的致癌性研究进展，目前存在的食品安全问题以及国内外相关食品卫生法规和管理现状。

关键词: 亚硝胺, 亚硝酸盐, 致癌效应, 食品安全

中图分类号:

R730.2

徐淼, 张倩男, 杨辉, 张立实, 贾旭东. 亚硝胺及前体化合物的致癌效应及其食用安全性研究进展[J]. 癌变·畸变·突变, 2018, 30(1): 76-79.

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亚硝胺及前体化合物的致癌效应及其食用安全性研究进展

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