乳腺癌易感基因1调控氧化损伤在神经退行性疾病中作用的研究进展

doi:10.3969/j.issn.1004-616x.2019.03.016

摘要/Abstract

摘要： 乳腺癌易感基因1（BRCA1）是一种重要的抑癌基因，其突变可导致基因组不稳定、DNA修复缺陷等，与遗传性乳腺癌、卵巢癌及多种肿瘤密切相关。研究发现BRCA1可减少细胞内的活性氧自由基水平，降低DNA氧化损伤。目前研究显示，氧化损伤是神经退行性疾病重要的发病机制之一。由于高水平的氧化代谢及抗氧化酶的相对缺乏，大脑对氧化应激特别敏感。神经元DNA氧化损伤与认知缺陷密切相关，且在各种神经退行性疾病病理改变的早期发生，具体机制尚不清楚。本文就BRCA1调控氧化损伤在神经退行性疾病中的作用作一综述。

关键词: 乳腺癌易感基因1, 神经退行性疾病, 氧化损伤, 线粒体DNA

中图分类号:

R114

梁辰, 靳翠红. 乳腺癌易感基因1调控氧化损伤在神经退行性疾病中作用的研究进展[J]. 癌变·畸变·突变, 2019, 31(3): 257-260.

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