癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (1): 8-011.doi: 10.3969/j.issn.1004-616x.1998.01.004

• 论著 • 上一篇    下一篇

137　Cs 事故受照人员外周血淋巴细胞微核的随防观察

白玉书1 　曹家珍2 　黄绮龙1 　张秀霞1 　关树荣1 　柴　文1 许绵文3 　李敬君3 　王　华2 　段汝萍4   

  1. 1 卫生部工业卫生实验所　北京100088 　2 黑龙江省卫生防疫站 3 哈尔滨医科大学　4 牡丹江市职业病防治所
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-01-30 发布日期:1998-01-30

A FELLOW2UP STUDY ON MICRONUCLEI OF PERIPHERAL BLOOD LYMPHOCYTE IN PERSONS EXPOSED TO 137CS RADIATION ACCIDENT

Bai Yushu1 ,Cao J iazhen2 , Huang Qilong1 , Zhang Xiuxia1 , Guan Shurong1 , Chai Wen1 , Xu Mi2 anwen3 , Li J ingjun3 , Wang Hua2 , Duan Ruping4   

  1. 1L aboratory of Indust rial Hygiene , Minist ry of Heal th , Beijing 100088 1L aboratory of Indust rial Hygiene , Minist ry of Heal th , Beijing 100088 2Heilongjiang Province Hygiene and Epidemic S tation , 3 Haerbin Medical University 4Mudanjiang City Instit ute of Occupational Disease
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-01-30 Published:1998-01-30

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摘要： 本文报道了39 例在5 个月内多次受到137Csγ射线源照射(累积当量剂量为5～2105mSv) ,受照人员外周血淋巴细胞微核的随防观察。结果表明,照后1 年直接法微核率受照和对照组接近,差异无显著性意义。此时,常规培养法微核率,受照组高于对照组,差异接近显著(011 > P > 0105) ,并且微核率与剂量之间存在相关关系。在照后5 年,采用CB 法测试微核,结果受照组微核率明显高于对照组,差异有非常显著性意义( P < 0101) 。表明CB 法提高了微核测试的灵敏度和可靠性。

关键词: 137Cs, 事故照射, 微核, 松胞素- B, 随访观察

Abstract: This paper resport s micronuclei of peripheral blood lymphocyte of 39 cases exposed to 137　Csγ2ray in a period of 5 months. The accumulated equivalent doses were 5～2105mSv. The result s show that micronucleus f requencies in the both groups of exposed and cont rol were very near . The difference was not significant . At that time , micronucleus f requencies using method of routine culture in exposed group were higher that those in the cont rol one , and they had correlated relationship with accumulated doses. At 5th year after irradiation , micronuclei were examined by cytokinesis2block micronucleus method. The result s show that the f requencies of micronucleus in exposed group were higher than those in the cont rol. The difference was very significant . It indicated that CB method increased precision and reliability for micronucleus assay.

Key words: 137　Cs, accidental radiation, micronucleus, cytochalasin2B, follow2up

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