同型半胱氨酸增加阿尔兹海默症患病风险相关机制的研究进展

doi:10.3969/j.issn.1004-616x.2018.05.015

摘要/Abstract

摘要： 目的：同型半胱氨酸（Hcy）是甲硫氨酸代谢中产生的一种含硫的非必需氨基酸，其在相关代谢酶及叶酸、维生素B6、B12等辅酶的作用下维持体内正常水平。编码Hcy代谢相关酶的基因缺陷及其辅酶缺乏可导致血浆Hcy浓度升高，引起高同型半胱氨酸血症（HHcy）——心血管疾病、神经退行性疾病和肿瘤风险因素。阿尔兹海默症（AD）是一种神经退行性疾病，其发病与年龄、遗传因素和环境因素密切相关，但AD发病机制目前尚未完全阐明。研究表明，Hcy可通过诱发β-淀粉样蛋白沉积、Tau蛋白过磷酸化、DNA损伤、氧化应激和自噬异常等诱发神经细胞损伤，增加AD风险。本文就高Hcy对AD风险的影响机制研究进展作一综述，为深入探究其分子机制提供新的思路和方法。

关键词: 同型半胱氨酸, 阿尔兹海默症, β-淀粉样蛋白, Tau, 自噬

中图分类号:

R34
Q291

胡夏练, 郭锡汉, 马晓玲, 汪旭. 同型半胱氨酸增加阿尔兹海默症患病风险相关机制的研究进展[J]. 癌变·畸变·突变, 2018, 30(5): 403-406.

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