酒精性肝病中的铁死亡机制研究进展

doi:10.3969/j.issn.1004-616x.2024.01.011

摘要/Abstract

摘要： 随着中国饮酒人数逐年增加，酒精性肝病（ALD）及相关的肝脏代谢性疾病患病率逐年递增，严重威胁公众健康。肝脏不仅是酒精的主要代谢器官，也是酒精损伤的重要靶器官，酒精诱导产生的活性氧（ROS）及氧化应激是其致肝损伤的重要机制之一。铁死亡是一种新型的细胞死亡，其发生与ROS、脂质过氧化和铁代谢平衡密切相关。酒精在肝脏的代谢过程中可诱导产生大量ROS，引起铁离子代谢紊乱，使氧化脂膜上多不饱和脂肪酸产生过多脂质过氧化物，破坏生物膜，诱导铁死亡。酒精诱导的铁死亡，使肝脏细胞部分死亡，出现脂质累积且无法及时代偿，对肝脏造成损伤，导致ALD。本文主要从线粒体产生ROS诱导脂质过氧化、胱氨酸/谷氨酸逆转运受体（system X_C-）和谷胱甘肽/谷胱甘肽过氧化物酶4（GSH/GPx4）系统及铁代谢等角度综述ALD中铁死亡机制的研究进展，为调控铁死亡防治ALD提供新思路。

关键词: 酒精性肝病, 铁死亡, 活性氧, 氧化应激, 线粒体, 铁代谢

中图分类号:

R114

李雪梅, 康萌, 万静之, 李澳忠, 刘启玲, 秦绪军. 酒精性肝病中的铁死亡机制研究进展[J]. 癌变·畸变·突变, 2024, 36(1): 66-69,76.

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