癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (3): 133-140.doi: 10.3969/j.issn.1004-616x.1998.03.003

• 论著 • 上一篇    下一篇

中药蛇床子水溶性提取物中化学成分的诱变性研究

殷学军1  向仁德2  刘德祥1  张新勇2  黄国香1  韩 英2  王河川1   

  1. 1兰州军区乌鲁木齐总医院临床医学研究所 830000  2 南京药物研究所 210009
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-05-30 发布日期:1998-05-30

A STUDY ON THE MUTAGENICITY OF CHEMICAL COMPOUNDS EXTRACTED FROM CNIDIUM MONNIERI ( L. ) CUSS USED IN CHINESE TRADITIONAL MEDICINE

Yin Xuejun1 ,Xiang Rende2 ,Liu Dexiang1 ,Zhang Xinyoug2 ,Huang Guoxiang1 ,Han Ying2 ,Wang Hechuan1   

  1. 1Instit ute of Clinical Medicine , Urumqi Geneal Hospital of L anz hou Com mand , PL A , Urumqi 830000 , 2Nanjing Instit ute of Materia Medica , Nanjing 210009
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-05-30 Published:1998-05-30

摘要: 本文采用Ames、活体小鼠骨髓细胞染色体畸变和骨髓多染红细胞微核试验对中药蛇床子水溶性提取物中9 种化合物(蛇床子素、佛手柑内酯、异虎耳草素、欧芹素属乙、花椒毒酚、花椒毒素、甲基嘧啶、尿嘧啶和1 种待定化合物) 进行了诱变性研究。结果表明,这9 种化合物既无移码突变和碱基置换效应,亦无诱发小鼠骨髓细胞染色体损伤和骨髓细胞抑制作用。

关键词: 蛇床子, 化学成分, 诱变性

Abstract: The mutagenicity of 9 water ext ract s of cnidium monnieri (L. ) Cuss was studied with Ames test and micronucleus induction and chromosomal aberration assays in vivo with mice. These compounds (osthol ,Bergapten Isopimpinellin mperatorin ,Xanthotoxol , Xanthotoxin , Thymine ,Uracil an and unknown one that need authenticating) were isolated f rom the water ext racts. No mutagenic effect in test systems was shown.

Key words: Cnidium minnieri (L. ) Cuss, Chemical compound, Mutagenicity