癌变·畸变·突变 ›› 2003, Vol. 15 ›› Issue (4): 234-236.doi: 10.3969/j.issn.1004-616x.2003.04.015

• 检测研究 • 上一篇    下一篇

盐酸吡格列酮对大鼠致畸性研究

廖　雪1，王　捷1，宋宏宇1，鲍　清1，乔　良1，张沈平2   

  1. 1.国家沈阳新药安全评价研究中心,辽宁　沈阳　110021；　2.沈阳第九人民医院,辽宁　沈阳　110024
  • 收稿日期:2003-03-10 修回日期:2003-06-28 出版日期:2003-10-30 发布日期:2003-10-30
  • 通讯作者: 廖　雪

STUDY OF TER ATOGENICITY OF PIOGILISTAZONE HYDROCHLORIDA IN RATS

LIAO Xue1， WANG Jie1， SONG Hong-yu1， et al   

  1. 1.National Research Center for New Drug Safety Evaluation ,Shenyang 110021,China;2.The Ninth Hospital of Shenyang, shenyang 110024,China
  • Received:2003-03-10 Revised:2003-06-28 Online:2003-10-30 Published:2003-10-30
  • Contact: LIAO Xue

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摘要： 目的：检测盐酸吡格列酮的致畸毒性。方法：应用Wistar大鼠进行致畸毒性试验。以6、24 ， 96 mg/kg 3个剂量组给药。 给药时间为大鼠妊娠后第6～15 d。结果：以96 mg/kg剂量经口投与Wistar妊娠大鼠，吸收胎和死胎数增加，各剂量组对胎鼠均有生长发育迟缓的影响。结论：盐酸吡格列酮可产生明显的胚胎毒作用，但对胎鼠无致畸作用。

关键词: 盐酸吡格列酮, 大鼠, 胚胎毒性, 致畸作用

Abstract: Purpose: This study was undertaken to determine the potentially teratogenic effects of pioglitazone hydrochloride to Wistar rats. Methods: The study was conducted with three groups orally administered with 6, 24, and 96 mg/kg doses continuously for 10 days from 6th to 15th day after gestation of rats. Positive (2 mg/kg Dikushuang) and negative controls (0.5 ％ CMCNa) were performed at the same time with the method. Results: the number of absorptive embryo and dead fetus increased in the high dose group (96 mg/kg). The stunt effect of pioglitazone hydrochloride to the fetus was observed in all dose groups. Conclusion: Pioglitazone hydrochloride showed obvious embryo toxicity, but no teratogenic effect to fetus was observed.

Key words: pioglitazone hydrochloride, Wistar rat, embryo toxicity, teratogenicity

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