癌变·畸变·突变 ›› 2004, Vol. 16 ›› Issue (3): 175-177.doi: 10.3969/j.issn.1004-616x.2004.03.015

• 研究简报 • 上一篇    下一篇

山萸肉水提液的毒性实验

张慧珍,吴逸明,吴拥军,呼世斌   

  1. 郑州大学医学院公共卫生学院,河南 郑州 450052
  • 收稿日期:2003-12-12 修回日期:2004-02-09 出版日期:2004-05-30 发布日期:2004-05-30
  • 通讯作者: 吴逸明

Study on the Toxicity of the Water Extract from the Pulp of Cornus

ZHANG Hui-zhen,WU Yi-ming,WU Yong-jun,et al   

  1. Department of Environmental Health,College of Public Health ZhengzhouUniversity,Zhengzhou 450052,China
  • Received:2003-12-12 Revised:2004-02-09 Online:2004-05-30 Published:2004-05-30
  • Contact: WU Yi-ming

摘要: 背景与目的:检测山萸肉水提液对脊椎动物胚胎的致畸作用,确定山茱萸果肉水提液的急性毒性和蓄积毒性。材料与方法:采用国家标准规定的急性毒性试验方法、蓄积毒性试验方法和致畸胎试验方法。结果:山茱萸水提液的LD50>10 g/kg,蓄积系数K>5;山萸肉水提液没有致畸胎作用。结论:山茱萸水提液没有急性毒性和蓄积毒性;山萸肉水提液对脊椎动物胚胎无致畸作用,为将山茱萸开发为功能性保健食品提供了科学的依据。

关键词: 山萸肉, 水提液, 急性毒性, 蓄积毒性, 胚胎毒性

Abstract: BACKGROUND & AIM:To check the embryo toxicity, acute toxicity, and accumulation toxicity of water extract from the pulp of cornus. MATERIALAND METHODS:Acute toxicity test,accumulation toxicity test and teratogenicity test were used in this study. RESULTS: The test result showed that:LD50>10 g/kg,accumulation coeffcient K>5. There was no significant difference between the water extract from the pulp of cornus and negative control,but there was significant difference compared to positive control. CONCLUSION: The water extract has no acute toxicity,accumulation toxicity on the mice,and no embryhotoxicity on the embryo of mice.

Key words: pulp of cornus, the matter extracted by water, acute toxicity, accumulative toxicity, embryotoxicity