Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (4): 236-238.doi: 10.3969/j.issn.1004-616x.1998.04.011

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STUDY ON THE ASSOCIATION OF THE N - ACETYLTRANSFERASE POLYMORPLISM WITH GASTRIC CANCER

Chen H , Zhang YF , Xu DP , Zhang XF , Sun CS   

  1. Fujian Madical Univercity , Fuz hou 　350004Abstract 　Polymorphism of metabalic enzyme is one of the factors relevant to the susceptibility to
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-07-30 Published:1998-07-30

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Abstract: Polymorphism of metabalic enzyme is one of the factors relevant to the susceptibility to environmental chemicals and heredicary predispositional to carcinogenesis. The polymorphism of N - acetylt ransferase among gast ric cancers is investigated and reported. It was found that 13 among 34 GC patient s (38. 24 %) were slow type of N - AT versus the referring figure 20/ 107 (18. 69 %) in the cont rols. Their gene f requencies were calculated as 0. 6183 and 0. 4323 respec tively , the difference was statistically significant ( P = 0. 022) . The OR of GC for slow N2AT was 2. 69 (1. 16 - 6. 27) , suggesting that slow N2AT should be considered as one possible aetiological factor of GC.

Key words: N-acetylt ransferase polymorphism, Genetic predispostion, Gastic cancer