Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (5): 289-293.doi: 10.3969/j.issn.1004-616x.1998.05.006

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DAMAGE EFFECTS ON CHROMOSOME AND MICRONUCLEI IN BONE MARROW CELLS OF MICE FOLLOWINGCHRONIC EXPOSURE TO 70 GASOLINE

Wang Hechuan1 , Li Ke2 , Yin Xuejun1 , Zhao Ruixin2 , Qiu Donghui1 , Liu Dexiang1 , Huang Yingtang3 , Huang Guoxiang1   

  1. 1Instit ute of Clinical Medicine , Urumqi General Hospital of L anz hou Com mand . PL A , Urumqi 　830000 　2 The cent re of medical ex perimental animal of XinJiang Com mand , Urumqi 　830000 　3 L anZhou medical higher college. PL A , L anZhou 　730000
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-09-30 Published:1998-09-30

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Abstract: The influence of a long2term exposure to 70 gasoline on chromosomes and micronuclei in bone marrow cells of mice was investigated. The animals were exposed to 70 gasoline at low (250mg/ m3) , medial (500mg/ m3) and high (1000mg/ m3) doses for 30 、60 、90d. After exposure for 90d (at high dose/ 1000mg/ m3) , the f requency of CA was significantly higher than that in the negative cont rol group. However , after exposure of r 60d (at high dose) and 90d (at mid/ high doses) , the f requency of micronuclei in polychromatic erythrocytes was significantly higher than that in the negative cont rol group. The data suggested that chronic exposure to gasoline may be hazardous to chromosome in bone marrow cells of mice.

Key words: Gasoline, Chromosome Aberration, Micronuclei