Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (2): 87-090.doi: 10.3969/j.issn.1004-616x.2002.02.006

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THE SIGNIFICANCE OF OVER-EXPRESSION OF p53 PROTEIN AND PROLIFERATION CELL NUCLEAR ANTIGEN IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS

TAO Yi-sheng1 , ZON G Yong-sheng2   

  1. 1. Department of Pathology , Bengbu Medical College , Bengbu 233003 ; 2. Departmant of Pathology , Sun Yat-Sen University of Medical Sciences , Guangzhou 510089 , China
  • Received:2001-09-17 Revised:2001-10-09 Online:2002-04-30 Published:2002-04-30
  • Contact: TAO Yi-sheng

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Abstract: Purpose : To study the over-expression of p53 protein and proliferation cell nuclear antigen (PCNA) in human esophageal basal cell hyperplasia , atypical hyperplasia , and carcinoma in situ , and to analyse the significance of the expression. Methods : 189 specimen of esophageal paracarcinoma epithelia and cancinoma in situ were tested for p53 and PCNA using immunohistochemical technic. Results : From basal cell hyperplasia to atypical hyperplasia to cancinoma in situ , the rates of p53 protein accumulation were 55 % , 79 % and 98 % ( P <0. 01) , respectively , and PCNA immunostain-positive cells increased in number as well. Conclusions : p53 protein accumulation occurs early in the pathogenesis of esophageal carcinoma. Over-expression of p53 protein and PCNA may serve as an indicator of precancerous lesions and malignancy in the human esophageal epithelium.

Key words: p53 protein, proliferation cell nuclear antige (PCNA), esophageal epithelium, atypical hyperplasia, carcinoma in situ

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