Abstract: Purpose and Methods : To study the potential mutagenicity of meloxicam , Ames test was carried out in TA97 , TA98 , TA100 , TA102 strains , chromosomal aberration test in Chinese hamster lung fibroblast sand micronucleus test in polychromatic erythrocytes in mice with and without S9mix. Results : No increase in the number of revertant colonies was found in the Ames test at a dose range from 0. 2 to 5 000μg per plate. These results were also negative in the micronucleus test and in the chromosomal aberration test at doses from 16 to 240 mg/ kg·bw. Conclusion : The mutagenicity of meloxicam was not observed in this study.

Key words: meloxicom, Ames test, chromosome aberration, micronucleus