无花果提取物致突变及抗突变研究①

doi:10.3969/j.issn.1004-616x.2002.03.011

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2002, Vol. 14 ›› Issue (3): 177-179.doi: 10.3969/j.issn.1004-616x.2002.03.011

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STUDY ON THE MUTAGENIC AND ANTIMUTAGENIC EFFECTS OF FIG EXTRACT

MA Guo-jian1, MENG Zheng-mu2, WANG Yi-xian1, ZHANG Qin-fen1, XUE Kai-xian1

1. Laboratory of Genetics, Cancer institute of Jiangsu Province, Nanjing 210009, China; 2. Department of Natural plant Chemistry, China Pharmaceutical University, Nanjing 210009, China

Received:2001-12-25 Revised:2002-02-10 Online:2002-07-30 Published:2002-07-30
Contact: 薛开先

Abstract

Abstract: Purpose : To study the mutagenic and antimutagenic effects of fig ext ract ( FE) . Methods : The invitro micronucleus test in human lymphocytes was used. The effect of FE on mutagenesis induced by MMC andγ-ray was studied. Results : Within the dosage of 0. 05～0. 45 g/ ml , FE had no mutagenicity , but inhibited γ-ray and MMC2induced micronucleus formation. FE also inhibited spontaneous micronucleus formation in old donors and tumor patient s. Conclusion : FE has an antimutagenic effect .

Key words: fig extract, micronucleus test, human lymphocyte

CLC Number:

R730. 1

MA Guo-jian, MENG Zheng-mu, WANG Yi-xian, ZHANG Qin-fen, XUE Kai-xian. STUDY ON THE MUTAGENIC AND ANTIMUTAGENIC EFFECTS OF FIG EXTRACT[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2002, 14(3): 177-179.

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STUDY ON THE MUTAGENIC AND ANTIMUTAGENIC EFFECTS OF FIG EXTRACT

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