Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 231-233.doi: 10.3969/j.issn.1004-616x.2003.04.014

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INFLUENCE OF HERBA LOENURI ON THE GENETIC DAMAGE IN MICE

ZHU Yu-zhuo1，PANG Hui-min1, LI Xiu-dong2, et al   

  1. 1.Department.of Medical Genetics, School of Basic Medical Sciences,Jilin University,Changchun 130021,China;2. Department of Toxicology,School of preventive Medicine,Jilin University,Changchun 130021,China; 3.Department of Biology ,College of Nursing,Jilin University ,Changchun 130021,China
  • Received:2003-06-10 Revised:2003-07-21 Online:2003-10-30 Published:2003-10-30
  • Contact: ZHU Yu-zhuo

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Abstract: Purpose:To observe the influence of herba loenuri on the genetic damage induced by Pb(CH3COO)2 in mice. Methods:The micronucleus test of mouse bone marrow cell and sperm abnormality test in mice were used in this study. Results: Herba loenuri could not induce either micronucleus formation in the mouse bone marrow cells or sperm abnormality in mice, but the frequencies of micronucleus formation in the mouse bone marrow cells and sperm abnormality in mice indued by Pb(CH3COO)2 were reduced significantly if herba loenuri and Pb(CH3COO)2 were given stimultaneously. Conclusion: Herba loenuri showed a protective effect ,namely antimutagenesis ,on genetic materials in mice.

Key words: herba loenuri, Pb(CH3 COO)2, micronucleus formation, sperm abnormality, genetic damage, antimutagenesis