Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (4): 320-322.doi: 10.3969/j.issn.1004-616x.2006.04.018

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Significance of Egr-1 and PTEN Protein Expression in Esophageal Epitheliosis and Carcinogenesis

WU Ming-yao, Wu Xian-ying, LI Qiao-shan, ZHENG Rui-ming   

  1. Department of Pathology, Medical College of Shantou University, Shantou，515041,Guangdong,China
  • Received:2005-03-16 Revised:2006-03-25 Online:2006-07-30 Published:2006-07-30
  • Contact: WU Ming-yao

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Abstract: BACKGROUND ＆ AIM: To investigate the expression of early growth response gene-1 (Egr-1 gene) and PTEN in esophageal epitheliosis and carcinogenesis, and the relation with the development of esophageal carcinoma. MATERIAL AND METHODS: Egr-1 and PTEN protein expression in 86 fresh tissue specimens, including esophageal mucosa above the upper surgical margin, carcinoma in situ and mucosa adjacent to tumor, were studied using immunohistochemical EnVision two step method. RESULTS: Egr-1 and PTEN protein were expressed in normal, proliferating and transformed malignant cells of esophageal epithelium. The expression of PTEN protein showed a different distribution pattern to that of Egr-1.The Egr-1 protein expression rose gradually and PTEN protein expression decreased gradually. CONCLUSION: Egr-1 and PTEN protein expression changes were closely related to the malignant transformation of esophageal epithelium. Egr-1 expression up-regulation and loss of PTEN expressions may be favorable markers and an early diagnostic indicator in patients with esophageal carcinoma.

Key words: Egr-1, PTEN, esophageal epithelium, carcinogenesis

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