富硒益生菌的急性毒性和遗传毒性试验

doi:10.3969/j.issn.1004-616x.2007.02.004

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (2): 96-098.doi: 10.3969/j.issn.1004-616x.2007.02.004

Previous Articles Next Articles

Acute Toxicity and Genotoxicity Tests of Selenium-enriched Probiotics

QIN Shun-yi, HUANG Ke-he

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China

Received:2006-08-31 Revised:2006-12-08 Online:2007-03-30 Published:2007-03-30
Contact: HUANG Ke-he

Abstract

Abstract: BACKGROUND ＆ AIM: To study the acute toxicity and genotoxicity of selenium-enriched probiotics. MATERIALS AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice, sperm abnormality test of mice were used. RESULTS: The oral acute toxicity study revealed that the LD50 of selenium-enriched probiotics was 18.49 g/kg in mice. The results of genotoxicity tests were all negative, including Ames test, micronucleus test and sperm shape abnormality test. CONCLUSION: Selenium-enriched probiotics showed certain toxicity but no genotoxicity in this study. Thus,selenium-enriched probiotics was safe at the daily-recommended dose(50 mg/person/day) and has the potential for development into functional foods.

Key words: selenium-enriched probiotics, acute toxicity, Ames test, micronucleus test, sperm abnormality test

CLC Number:

Q939.9

QIN Shun-yi, HUANG Ke-he. Acute Toxicity and Genotoxicity Tests of Selenium-enriched Probiotics[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(2): 96-098.

[1]	YANG Yu, HUANG Yali, LIN Fei, TANG Long. Acute toxicity and genotoxicity of antitumor serum thymic factor 9 peptide [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 57-61.
[2]	XIA Qiyue, YUE Qianlan, DOU Jiexiong, ZHUANG Siqi, LIU Keliang. Toxicological test of orally administered sodium sulfide in rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 62-66.
[3]	GE Xianmin, LI Bin, HUANG Chaopei, GAO Yuqiu, LUO Hailan, YANG Hui, WANG Yanwu, WEN Pingjing, LAN Guanghua, CHEN Huanhuan, MENG Qin, LUO Liuhong, DENG Yueqin, LIU Shuaifeng, WU Xiuling. Acute oral toxicity and mutagenicity of combined drugs for anti HIV [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 466-469,474.
[4]	CAI Qi, GAO Deyu, SHI Jianfeng, YU Hao, HAN Yan, YANG Liu, ZHAO Lei, WANG Zhaoxu. Potential use of tree shrew as an animal model for the micronucleus test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 370-374,382.
[5]	HUANG Chaopei, QIN Huiyan, ZHANG Lujuan, WANG Yanwu, HE Li, FU Weizhong. Study on acute toxicity and mutagenicity of Aronia melanocarpa extract in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 474-476.
[6]	CAO Yiyi, LIU Weiying, YOU Xinyue, XI Jing, Chen Ruixue, ZHANG Xinyu, LUAN Yang. In vitro genotoxicity evaluation of BDE-3, BDE-47 and BDE-209 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 15-20,28.
[7]	ZHOU Su, LI Rui, ZHU Hongyan, ZHANG Zhichao, FANG Jing, TANG Liming. An optical density method for determining bacterial concentrations in the Salmonella typhimurium reverse mutation assay [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 62-66.
[8]	WANG Quankai, XIE Guangyun, MA Shunpeng, GUO Haoran, WUHAN Baolier, SONG Jiayang, XU Jianning. Genotoxicity evaluation of glycidyl methacrylate [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 479-482.
[9]	ZHENG Kai, WANG Bingyu, XU Xinyun, GENG Hong, HUANG Haiyan, LIU Wei, LONG Dingxin. Mutagenicity of PM_2.5 samples from Shenzhen and Taiyuan [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 483-487.
[10]	XIA Ying, FU Shaohua, ZHANG Yinjing, WANG Wei. Genetic toxicity test of a pesticide, Paichongding [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 136-139.
[11]	CAO Yiyi, XI Jing, TANG Weifeng, YOU Xinyue, LIU Weiying, LUAN Yang. Genotoxicity evaluation of triclosan in vitro [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(1): 71-75.
[12]	JIANG Yi, JIA Xiaohui, LI Peining, CHEN Xiujuan, LIU Donghong, LIU Xiangmei. Ames mutagenicity assay on five plastic surface chemicals in racetrack [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(4): 309-312.
[13]	WANG Zhi, LING Xi, ZHANG Guowei, GAO Jianfang, ZOU Peng, JING Che, LIN Zhetao, LIU Jinyi, CAO Jia, AO Lin. Effect of folic acid on DNA demethylation and chromosomal damage in mice after their inhalation exposure to 1, 3-butadiene [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(3): 189-193.
[14]	SHAN Chun, HU Peili, ZHANG Luyong, LIU Ting, LIN Fei. Different induction and cryopreservation methods on metabolic activities of rat liver S9 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 388-392.
[15]	CHEN Xiujuan, LIU Xiangmei, PANG Zengxiong, LIU Donghong, LIU Ying, LUO Xuelian, CHEN Hanjin, HUANG Yufeng. Acute and genetic toxicity of aqueous extract of Eriobotrya japonica leaves [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 403-406.

Acute Toxicity and Genotoxicity Tests of Selenium-enriched Probiotics

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments