育发剂致突变性2种试验方法的比较

doi:10.3969/j.issn.1004-616x.2007.06.019

Abstract

Abstract: BACKGROUND ＆ AIM: To investigate suitable methods for detecting mutagenicity of hair restorers. MATERIALS AND METHODS: Using Ames test and mouse lymphoma assay (MLA) to evaluate the mutagenic effects of three kinds of hair restorers. RESULTS: Three hair restorers had strong bacteriostatic and bacteriocidal effects on Salmonella typhimurium, and no mutagenicity was observed. In MLA test, sample No.1 and sample No.3 had no mutagenic effects at concentrations tested, However, in No.2 hair restorer, TK locus mutation frequency was significantly higher than that of control group (P<0.05)at high dose. CONCLUSION: MLA test may be a complementary method used to detect the mutagenic effect of hair restorer.

Key words: hair restorer, mutagenicity, Ames test, mouse lymphoma assay

CLC Number:

R730.45

SONG Rui-xia, RUAN Hong-jie, ZHANG Li-xia. Comparison between Two Methods of Detecting Mutagenicity of Hair Restorers[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(6): 497-500.

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Comparison between Two Methods of Detecting Mutagenicity of Hair Restorers

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