蕨菜黄酮提取物的急性毒性和致突变性

doi:10.3969/j.issn.1004-616x.2008.02.020

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (2): 157-159.doi: 10.3969/j.issn.1004-616x.2008.02.020

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Studies on the Acute Toxicity and the Mutagenicity of Flavonoids Extracts

CHEN Cun-wu, CHEN Nai-fu, ZHANG Li, ZHOU Yong-bao, LI Yang

Department of Chemistry and Life Science, West Anhui University, Lu'an 237012, Anhui, China

Received:2007-09-10 Revised:2007-10-24 Online:2008-03-30 Published:2008-03-30

Abstract

Abstract: BACKGROUND AND AIM: To study the acute toxicity and the mutagenicity of the flavonoids extracted from pteridium aquilinum var. latiusculum. MATERIALS AND METHODS: The oral acute toxicity test, micronucleus test of bone marrow PCE cell and sperm shape abnormality test were carried out. RESULTS: LD50 of the flavonoids extracts from pteridium aquilinum var. latiusculum in rats was more than 20.0 g/kg. The micronucleus rates and sperm abnormality rates in all doses were negative(P>0.05). CONCLUSION: The flavonoids extracted from pteridium aquilinum var. latiusculum was considered a substance with no toxicity and mutagenic activity in this study.

Key words: pteridium aquilinum var. latiusculum, flavonoid, acute toxicity, micronucleus, abnormality

CHEN Cun-wu, CHEN Nai-fu, ZHANG Li, ZHOU Yong-bao, LI Yang. Studies on the Acute Toxicity and the Mutagenicity of Flavonoids Extracts[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(2): 157-159.

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Studies on the Acute Toxicity and the Mutagenicity of Flavonoids Extracts

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