Abstract: BACKGROUND AND AIM: To explore the expression of glucose transporter1(GLUT1) and Annexin_1 in endomentrial carcinoma , and investigate their correlations to clinicopathologic features of endometrial carcinoma. MATERIALS AND METHODS: The expression of GLUT1 and Annexin_1 were examined in 65 specimens of endomentrial carcinoma,27 endometrial dysplasia and 21 proliferative endometria by S_P immunohistochemistry. Their correlations to clinicopathologic features of endometrial carcinoma were analyzed . RESULTS: The positive expression rates of GLUT1 in proliferative endometrium,endometrial dysplasia and endometrial carcinoma were 28.6％,59.3％ and 81.5％ respectively,showing an increasing trend. There was a significant difference between groups (P<0.05). The positive expression rates of Annexin_1 in the above three groups were 85.7％,55.6％ and 49.2 ％, respectively. The rates were significantly lower in endometrial carcinoma than in normal endometrium(P<0.05).The higher expression of GLUT1 was correlated to histological grade and myometrial invasion, but not to pathologic stage,lymph node metastasis and histological type. The lower expression of Annexin_1 was not correlated to any of those features.Negative correlation was found between GLUT1 and Annexin_1 expression(r=-0.596,P=0.000). CONCLUSION: under_expression of Annexin_1 and over_expression of GLUT1 may be involved in carcinogenesis and development of endometrial carcinoma. This may contribute to early diagnosis and prognostic evolution of endometrial carcinoma.

Key words: endometrial carcinoma, glucose transporter1, Annexin_1, immunohistochemistry