珍珠祛斑美容片的急性毒性和遗传毒性试验研究

doi:10.3969/j.issn.1004-616x.2008.06.019

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (6): 487-489.doi: 10.3969/j.issn.1004-616x.2008.06.019

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Acute Toxicity and Genotoxicity Tests of Pearl Anti_spot Cosmetic Slice

LIU Dong-ying, MEI Song, FU Ying, LAI Wei-qi, CHEN Jian-guo, WANG Yin

Zhejiang Academy of Medical Science, Hangzhou 310013, China

Received:2008-01-15 Revised:2008-03-19 Online:2008-11-30 Published:2008-11-30

Abstract

Abstract: BACKGROUND AND AIM: To study the acute toxicity and genotoxicity of pearl anti-spot cosmetic slice. MATERIALS AND METHODS: Acute toxicity test, Ames test, micronucleus test of bone marrow PCE cell in mice, sperm abnormality test of mice were used． RESULTS: The oral acute toxicity study revealed that the maximal tolerance dose (MTD) of pearl anti-spot cosmetic slice was greater than 20.0 g/kg in mice. The results of genotoxicity tests were all negative, including Ames test, micronucleus test and sperm shape abnormality test. CONCLUSION: Pearl anti-spot cosmetic slice showed no acute toxicity and genotoxicity in this study. Thus, pearl anti-spot cosmetic slice is safe at the daily recommended dose(2.0 g／person／day)．

Key words: pearl anti-spot cosmetic slice, acute toxicity, Ames test, micronucleus test, sperm abnormality test

LIU Dong-ying, MEI Song, FU Ying, LAI Wei-qi, CHEN Jian-guo, WANG Yin. Acute Toxicity and Genotoxicity Tests of Pearl Anti_spot Cosmetic Slice[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(6): 487-489.

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Acute Toxicity and Genotoxicity Tests of Pearl Anti_spot Cosmetic Slice

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