生物活性肽粉的急性毒性和致突变性试验

doi:10.3969/j.issn.1004-616x.2009.04.014

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2009, Vol. 21 ›› Issue (4): 306-308.doi: 10.3969/j.issn.1004-616x.2009.04.014

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Acute Toxicity and Genotoxicity of Bioactive Peptide Powders

ZHOU Wen; LI Hui; CHEN Min

Disease Prevention and Control Center of Shandong; Ji,nan 250014;China

Received:2008-08-28 Revised:2008-10-10 Online:2009-07-30 Published:2009-07-30
Contact: ZHOU Wen

Abstract

Abstract: BACKGROUND AND AIM To study the safety of bioactive peptide powders. MATERIALS AND METHODS Acute toxicity test of mice; Ames test; micronucleus test of bone marrow PCE cell in mice; sperm shape abnormality test of mice were used. RESULTS Bioactive peptides revealed a LD50>10 g/kg in mice. The results of genetic toxicity test were all negative; including Ames test; micronucleus test and sperm shape abnormality test. CONCLUSION The bioactive peptide powders was a substance with no toxicity and no genotoxicity under our experimental conditions.

Key words: bioactive peptides;acute toxicity test;micronucleus test;sperm shape abnormality, Ames test

CLC Number:

994.4

ZHOU Wen, LI Hui, CHEN Min. Acute Toxicity and Genotoxicity of Bioactive Peptide Powders[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2009, 21(4): 306-308.

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Acute Toxicity and Genotoxicity of Bioactive Peptide Powders

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